Interestingly, in DU145 and PC3 models of prostate cancer, the addition of iron induced the expression not only of FTH1, but also of FTH1P11 and FTH1P16, two pseudogenes whose expression is not regulated by IREs, while iron depletion down-regulated FTH1, FTH1P11, and FTH1P16 [56]. This evidence concerns the gene FTH1 and Familial prostate cancer.