By using co-immunoprecipitation experiments, Zheng et al. showed that the binding of FTH1P3 to LSD1 would be important to recruit the demethylase activity of LSD1 on the promoter regions of the Metalloproteinase inhibitor 3 (TIMP3), thus epigenetically repressing TIMP3 and accelerating the tumorigenesis of NSCLC. Here, TIMP3 is linked to non-small cell lung carcinoma.