TDEVs not only contain the typical exosomal markers, like tetraspanins (CD81, CD63), ESCRT proteins (TSG101), heat shock proteins (HSC70), but also tumor-specific markers such as TAAs (Her2/Neu, Mart1, TRP, GP100), MHC molecules, TNF, Fas Ligand, CD73 or Galectin-9 [82,86]. This evidence concerns the gene TNF and neoplasm.