Additionally, macrophages can produce inflammatory cytokines, including IL-6, IL-8, IL-1β, CCL2, TNF-α and granulocyte colony-stimulating factor (G-CSF), also via NFκB and TLR-dependent by TDEVs stimulation in breast [95] and gastric cancer [96]; the later with increasing tumor cell growth, migration and invasion [96]. The gene discussed is TNF; the disease is neoplasm.