The gene expression studies of selected hypermethylated genes (CDKN2A, GATA4, DLEC1, HDAC10, PYCARD, SCGB3A1/HIN1) in normal and neoplastic adrenocortical tissues, revealed reduced gene expression in benign tumors and malignant ACCs vs. normal adrenocortical tissue, while treatment with the 5-aza-2’-deoxycytidine of ACC H-295R line cells, increased the expression of these hypermethylated genes [42]. Here, SCGB3A1 is linked to benign neoplasm.