The putative targets and functional effectors of miR-26b are the lymphoid enhancer binding factor 1 (LEF1) [80], overexpressed in chronic lymphocytic leukemia and in the monoclonal B cells lymphocytosis, a pre-lymphomatous condition [81], and cyclooxygenase-2, COX2 [79]. Here, PTGS2 is linked to B-cell chronic lymphocytic leukemia.