This variability depends, as thoroughly discussed, on stroke subtype (and, consequently stroke’s metabolic and systemic background) and infarct size but could also depend upon genetic polymorphism of candidate genes of inflammatory cytokines, as proinflammatory genetic genotypes (IL-6 GG, ICAM-1 EE, E-Selectin AA) are significantly more common in subjects with stroke history [98,118]. This evidence concerns the gene SELE and stroke disorder.