Although most studies comparing EVs and cf-DNA monitored the presence of mutations in a single gene (e.g., EGFR or BRAF) by PCR, more comprehensive genetic testing to identify less common targetable alterations in BRAF, ROS1, RET, NTRK, MET, and ERBB2 could also improve outcomes for a subset of NSCLC patients [35]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.