BMPR2 and heritable pulmonary arterial hypertension: For instance, to understand the effect of bone morphogenetic protein receptor 2 (BMPR2) mutations in ECs, Gu et al. [99] used ECs differentiated from hiPSCs of patients with familial PAH (FPAH), CRISPR/Cas9 corrected FPAH, healthy individual, and unaffected BMPR2 mutation carrier.