FBXW7 and neoplasm: To further determine whether the effect of FBXW7 knockout on M2 macrophage polarization was indeed responsible for tumor progression, we subcutaneously injected wild-type C57BL/6 mice with a mixture of LLCs and FBXW7f/f or Lysm+FBXW7f/f M2-polarized macrophages at a 1:1 ratio (Figure 5E).