CCNE1 and neoplasm: The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is a well-known tumor suppressor that mediates degradation of several oncoproteins including c-Myc, cyclin E, and Mcl-1, which play a critical role in regulating the cell cycle, DNA damage and repair, signal transduction, and transcription factor activity in tumor cells [24] [25].