Of these, HDAC1, NRF1, POU5F1, TFCP2L1, MYOG, NKX3-1, MITF, MEF2A, MZF1, NR2F1, PRDM1, FOXP1, MZF1, and ONECUT1 are involved in cell proliferation/stem cell maintenance, whereas HNF3, FOXA2, HNF4A, and ONECUT1 (HNF6) are involved in diabetes/energy response, and E2F1 is involved in DNA damage repair. The gene discussed is E2F1; the disease is diabetes mellitus.