SHMT1 and ischemic stroke: In multivariate analysis, the levels of SHMT1 methylation (p < 0.001, OR [95% CI] = 1.07 [1.04-1.09]) and HDL (p < 0.001, OR [95% CI] = 0.02 [0.004-0.13], Table 3) were strongly related to ischemic stroke.