SHMT1 and Stroke: SHMT1 methylation was also associated with Hcy in stroke cases (stroke cases, p = 0.034, controls, p = 0.950; total, p = 0.011) and HDL in controls (stroke cases, p = 0.146, controls, p < 0.0001, total, p = 0.001) using regression analysis adjusted for age, sex, BMI, Hcy, HDL, and LDL.