As shown in Figure 4, the ROC analysis of curve showed that SHMT1 methylation had acceptable diagnostic value for ischemic stroke regardless of sex (area under the curve [AUC] = 0.71, p < 0.001; male patients, AUC = 0.62, p = 0.032; and female patients, AUC = 0.79, p < 0.001). Here, SHMT1 is linked to ischemic stroke.