MICU1 and cardiac hypertrophy: Therefore, the present study was designed to identify the following: (i) whether MICU1 expression is altered in Ang-II-induced cardiac hypertrophy, (ii) whether MICU1 deficiency aggravates cardiac hypertrophy, and if so, (iii) whether melatonin suppresses oxidative stress and attenuates mitochondrial abnormalities in cardiac hypertrophy by activating MICU1.