MICU1 and Interstitial cardiac fibrosis: Notably, MICU1 supplementation ameliorated the enlargement of cardiomyocytes, attenuated cardiac interstitial fibrosis (Figure 4C–4E), decreased the ratios of HW/TL and LVW/TL (Figure 4F–4G), and rescued cardiac dilation function (Figure 4H–4K) in hypertrophic myocardium.