While cccp‐1 knockout in C. elegans results in a neurologic phenotype of impaired and slowed locomotion,2 homozygous Otg1/CCDC186 knockout mice show severe postnatal growth retardation and preweaning lethality as well as impaired glucose metabolism with hypoglycemia and low levels of serum insulin.22 The gene discussed is CCDC186; the disease is Hypoglycemia.