Within a large sequencing study of 1000 cases from Saudi‐Arabia, a homozygous loss‐of‐function variant in CCDC186 (NM_018017: c.610C>T; p.(Gln204Ter)) was identified in a patient with failure to thrive, global developmental delay, hypotonia, brain atrophy as well as undescended testis, micropenis, and poor vision.13 This evidence concerns the gene CCDC186 and male reproductive organ cancer.