First at the transcriptional level, TTP expression could be directly induced by transcription factor ELK‐1 and EGR‐1 through binding the TTP promoter38; Methylation of a specific single CpG site (−500 bp) within the TTP promoter region could suppress TTP transcription in HCC cell and blockade of DNA methylation in this CpG site could increase TTP expression.11 The gene discussed is ZFP36; the disease is hepatocellular carcinoma.