It has been reported that H2AFY is significantly augmented in breast cancer cells and hepatocellular carcinoma (HCC) compared with normal control cells,35 up‐regulated H2AFY also related to poor prognosis of breast cancer by driving overexpression of HER‐2 and might favour HCC progression through pathway of p38 MAPK.36, 37. The gene discussed is ERBB2; the disease is hepatocellular carcinoma.