ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The present study extends findings of these studies by providing an example of an obesity-independent association of insulin resistance with adiponectin levels, as there was a significant indirect correlation between HOMA-IR and mean level of total adiponectin; also, a multiple regression analysis revealed HOMA-IR to be one of the significant independent predictors of total adiponectin level.