The CAPN1ΔPF4 mice were also protected from diabetes-induced vascular inflammation as while STZ-treatment resulted in a decrease in PAR-1 and an increase in ICAM-1 expression in aortic endothelial cells from wild-type mice no such changes were observed in aortae from mice lacking platelet CAPN1 (Fig. 6e). This evidence concerns the gene ICAM1 and diabetes mellitus.