PopPK analyses have shown that some baseline disease-related characteristics (e.g., B cell count and tumor sum of the product diameters) are statistically significant covariates for the PK of R (31), G (32), and pola (9), suggesting the potential for a B cell related drug-drug interaction between pola and R. The pCC approach was used for this analysis with all patients assumed to have R/R disease (the reference covariate value), which allowed unbiased analysis of pooled data across previously untreated and R/R patients for this analysis. Here, POLA1 is linked to neoplasm.