GPT and diffuse large B-cell lymphoma: When the NCI criteria (16) of hepatic impairment was applied to a cohort of 1341 previously untreated DLBCL patients, it was found that 5.8% of patients had moderate or severe hepatic impairment and 8.8% of patients would have been excluded from the pola clinical studies if the inclusion/exclusion criteria related to AST/ALT and total bilirubin levels were applied (Table VII).