The importance of this molecule in age-related decline has been demonstrated: Type I IFN responses are increased with age, IFN-β expression in the brain is associated with cognitive decline, and injection of IFN-β expressing viral vectors into an adult mouse can induce an old phenotype (Baruch et al., 2014; Deczkowska et al., 2017). This evidence concerns the gene IFNB1 and Mental deterioration.