PIK3CA and colorectal carcinoma: Multiple somatic driver mutations were identified, all previously associated with the tumor type in which the mutation was identified, such as BRAF (c.1799T > A, p.Val600Glu) in CRC and melanoma, and PIK3CA (c.1624G > A, p.Glu542Lys) in breast cancer (Figure 1—figure supplement 2).