ASIC3 and Granuloma: Whereas both inflammation models produced a statistically significant difference for mechanical hyperalgesia between genotypes (after 24 hours, i.e. ASIC3−/- mice showed less hyperalgesia compared to WT), only carrageenan produced a statistically significant thermal hyperalgesia difference (after 24 hours, i.e. ASIC3−/- mice showed less hyperalgesia compared to WT); furthermore, the ASIC3−/- displayed a reduction in the inflammatory features (granuloma and vasculitis) of muscle compared to WT by ~65% [77], which may perpetuate differences in hyperalgesia between genotypes.