In rats, 58% of DRG neurones projecting to pleural and pulmonary tissues displayed ASIC3-like currents [121] and rASIC3-like currents have also been reported in vagal pulmonary sensory neurones [122], thus, sensory neurones are well equipped to respond to tissue acidification associated with respiratory disease via ASIC3. Here, ASIC3 is linked to respiratory system disorder.