CFTR and cystic fibrosis: Human lung tissues show co-expression of CFTR and ASIC3, with ASIC3 levels upregulated in CF lung sections associated with the increased inflammation compared to non-CF tissue; additionally, hASIC3 was found to be co-expressed with CFTR in the following human epithelial cell lines, airway submucosal (Calu-3), bronchial (16HBE14o), colonic (T84) and pancreatic (CFPAC) cells, all from parts of the body that have been shown to develop acidic changes in CF patients [123].