As expected with ASIC3 activity, mouse ND gastric and gastroesophageal ganglia neurones displayed greater currents with increased acidity, pH 4.0 vs pH 7.0 (control); however, whereas ASIC3 appears to play a role in acid sensation, perhaps important during dyspepsia, TRPV1 appeared to play a greater role in broader chemo- and mechanosensation [117]. This evidence concerns the gene ASIC3 and dyspepsia.