The link between ASIC3 and blood pressure regulation is further supported by the human genetic polymorphism rs2288646-A found in Taiwanese individuals, which is associated with a higher frequency of higher systolic and diastolic blood pressure, allele frequency being 9.7% amongst those with hypertension [105]; however, the effect of this polymorphism on channel function or expression is yet to be determined. The gene discussed is ASIC3; the disease is hypertensive disorder.