This is because inhibition of ASIC3 with the sea anemone Anthopleura elegantissima toxin 2 (APETx2), in rat models of epilepsy leads to: shortened latency to seizure, increased incidence of generalized tonic-clonic seizures and significantly decreased frequency of action potential firing in interneurons; thus, ASIC3 may play a protective role through dampening action of potential frequency in post-synaptic neurones [55]. The gene discussed is ASIC3; the disease is epilepsy.