While vancomycin-pretreated WT, and Sigirr-/- mice showed no inflammation in their ceca at baseline (Figure 1e), at day 5 post p19A infection, higher levels of inflammatory cell infiltration, increased submucosal edema and epithelial damage were seen in the ceca of Sigirr-/- mice as compared to WT mice (Figure 1e,f). Here, SIGIRR is linked to infection.