Vancomycin treated Sigirr-/- mice were infected with p19A or DH10B, followed by oral administration of PBS (vehicle control) or different FimH antagonists (1A-HM and 7 CD-HM, 10 mg/kg per mouse)37 at 2 h post-infection, as well as at days 1, 2 and 3 post-infection. The gene discussed is SIGIRR; the disease is infection.