As expected, Ts2 Veh mice showed a significant increase in β-CTF/α-CTF ratio compared to respective euploids (Fig. 8(G, I); **p < 0.01, Eu Veh Vs Ts2 Veh: + 40%) with a relevant contribution of genotype (Table 2; F (1,17) = 24.1, ***p < 0.001) that confirms a tendency toward the APP amyloidogenic processing in our DS model. The gene discussed is APP; the disease is Dravet syndrome.