CXCR2 and cancer: It chemotactically recruits MDSC by interacting with CXCR2.56 In cancer patients, CXCR2 chemokine receptor agonists lead to the extrusion of neutrophil extracellular traps (NETs) by neutrophils, and G-MDSCs.94 The CCL2/CCR2 signaling axis recruits M-MDSCs to distant organs.