It has been associated with MDSC accumulation and NK-cells immunosuppression.120 IL-1β expressing tumor cells express higher levels of G-CSF, multiple CXC chemokines, and vascular adhesion molecules that mediate G-MDSCs infiltration and enhance angiogenic and immunosuppressive properties.49 Activation of MDSCs by IL-1β enhances their immunosuppressive activities through NF-κB signaling. This evidence concerns the gene IL1B and neoplasm.