MLH1 and endometrial cancer: The results in Tables 1, 2, and 3 showing the consequences of having or not having hysterectomy and/or BSO at various ages demonstrate for path_MLH1, path_MSH2, and path_MSH6 heterozygotes a small cumulative cancer risk (2%) up to 40 years of age, and a more substantial risk (1.1% to 2.5% annual incidence)1 for endometrial cancer from 40 years of age onward.