If risk-reducing hysterectomy were performed at 25 years of age, endometrial cancer before 50 years would be prevented in 15%, 18%, 13%, and 0%, in patients with heterozygous path_MLH1, path_MSH2, path_MSH6, and path_PMS2 variants, respectively, and death in 2%, 2%, 1%, and 0%. Here, MSH6 is linked to endometrial cancer.