MRC1 and colonic neoplasm: Daily intake of acetyl-salicylic acid (aspirin) has been demonstrated to reduce colon cancer risk in heterozygotes for path_MMR variants by about 50%.12 A recent study also demonstrates a reduction in endometrial cancer incidence in heterozygotes for path_MMR variants taking acetyl-salicylic acid.13 The results in both of these reports were not stratified by MMR gene or age.