Risk-reducing hysterectomy at 40 years of age was estimated to prevent endometrial cancer by 50 years in 13%, 16%, 11%, and 0% of patients and death in 1%, 2%, 1%, and 0% for path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes, respectively. This evidence concerns the gene PMS2 and endometrial cancer.