The genes at the hub of the pathways are BCL2, APAF1, TNF and SMAD2. The top up-regulated genes alter the NF-κB and TGF pathways and function as tumour suppressor genes; the top down-regulated genes repress apoptosis and prevent Torc2 signalling and play a role in gene regulation. This evidence concerns the gene NFKB1 and neoplasm.