Previous studies indicated that TriCurin repressed the expression of E6 and E7 and activated the expression of p53 in HeLa cells.10 In an HPV (+) chimeric mouse model of cervical cancer, both TriCurin and curcumin suppressed E6 and induced p53, acetyl-p53 and caspase-3. The gene discussed is TP53; the disease is cervical carcinoma.