FOXP3 and cancer: There was no clear pattern to the number of FoxP3+ regulatory cells/mm2 at each disease level in epithelial tissue and high heterogeneity in total tissue, while there was an increase across lgCIN, hgCIN, and cancer in lesion-adjacent stromal tissue with no studies reporting FoxP3 levels in normal stroma (Figs. 2E and S1E).