FOXP3 and cervical carcinoma: Indeed, a previous analysis, albeit of only two studies, concluded that high levels of FoxP3+ cells are associated with significantly reduced overall survival in cervical cancer.103 Our findings in the FoxP3 meta-analysis and CD25 qualitative summary also suggest that an increased presence of regulatory T-cells is associated with more severe disease, that regulatory T-cell infiltration may inhibit the immune response at all stages of cervical carcinogenesis, and that this effect may be greater for HPV16, the most highly carcinogenic HPV type.