More specifically, it allows the activation of the mitogen-activated protein kinase (MAPK) pathway responsible for the activation of downstream p90RSK, thus inhibiting the pro-apoptotic protein Bad.47 In prostate cancer, PI3K/Akt signalling is activated downstream by the involvement of Notch and activation of the Hedgehog pathway. The gene discussed is AKT1; the disease is prostate carcinoma.