In hepatoma cells, a low level of DR4/DR5 expression was associated with resistance of the TRAIL-induced apoptotic cascade even if upregulation of TRAIL mRNA was observed.136 Yet, no modulation in DR4/DR5 expression was observed between attached and detached human colon epithelial cells where TRAIL resistance was shown. Here, TNFSF10 is linked to hepatocellular carcinoma.