TNFRSF10B and glioblastoma: Among them, miR-21 seems to play a pivotal role in modulating the expression of both E-cadherin and DR4/DR5 as observed in a glioblastoma model.87 In this study, the Hedgehog inhibitor NPV-LDE-225 blocked the EMT process and allowed an increase in the efficiency of TRAIL-induced apoptosis by increasing DR4/DR5 and E-cadherin expression.