FAT1 is a cadherin-like protein with tumour-suppressor functions, which plays a central role in developmental processes and cell communication.94,95 This adhesive molecule is highly expressed in several foetal epithelia, but its mutation leads to an aberrant activation of the WNT signalling pathway resulting in tumorigenesis.96 In glioblastoma cells, FAT1 acts as a negative regulator of DR4/5. The gene discussed is TNFRSF10A; the disease is glioblastoma.