Furlow et al. demonstrated that metastatic breast cancer cells with a PANX1 channel-activating mutation gained a survival advantage due to an increase in the release of ATP, which was modulated via PANX1 when the breast cancer cells became lodged in the microvasculature.8 The likely mechanism is that the cellular deformation induced by capillaries forces the stretching of the cellular membrane, which, in turn, opens PANX1 channels. Here, PANX1 is linked to breast cancer.