PIEZO2 and breast cancer: Piezo2 channels, which are involved in sensing gentle touch and proprioception, have been shown to be upregulated in the breast cancer cell line MDA-MB-231-BrM2, a subpopulation of MDA-MB-231 cells that specifically metastasises to the brain.59 Knockdown of Piezo2 in MDA-MB-231-BrM2 cells resulted in an impaired ability to cross constricted channels of 3 μm, suggesting that Piezo2 channels might also confer an advantage in migration through confined spaces.59