TWIST2 and cancer: Cognart et al. reported that the transcription factor Twist2, which has previously been associated with cancer progression,90,91 was upregulated in the metastatic line MDA-MB-231 after transiting capillary constrictions.9 Additionally, E-cadherin downregulation could be observed upon constriction transit,9 although the role of this protein in cancer progression is currently under debate.92 These results suggest that capillary constriction forces might be able to induce genomic changes that can promote EMT and cell invasiveness.