SMARCA4 and cancer: Since BRG1 is a major member of the chromatin remodeling complex, which regulates the expression of many genes, overexpression of HA-BRG1 increased the protein and mRNA levels of USP24, suggesting that USP24 and BRG1 can regulate each other through modulating the protein stability and transcriptional activity, respectively, of the other, which may be critical for cancer progression (Fig. 1C(a)).