In MM patients, the frequencies of IFNγ+ cells in circulating CD4+PD-1+ and CD8+PD-1+ T cells were significantly lower compared with the same donor cell subsets but remained comparable to CD4+PD-1− and CD8+PD-1− T cells, respectively (Fig. 4C,E, Supplementary Fig. S5B). This evidence concerns the gene CD8A and Miyoshi myopathy.