We have found two novel Vcan sites phosphorylated in control cells, which were downregulated in TNFα treated cells, Ser 1621 and Ser 1622, and, combined with the fact that Vcan was the only protein listed as significantly regulated in all three analysis performed in this paper, we hypothesize that Vcan may be a major player in the progression of insulin resistance in adipocytes (Fig. 7A,C). The gene discussed is VCAN; the disease is Insulin resistance.