EDNRB and cancer: The paw model provided two advantages over the tongue model: 1) the HSC-3 paw model was used in our previous study to test the effect of EDNRB re-expression on proliferation, so our results were directly comparable to the those of the previous study; 2) the paw volume could be measured throughout the experiment to track cancer growth, whereas repeated measurements were not possible with the tongue cancer model without sedating the mouse.