The average tumor volume for the four groups was: 58 ± 8.68 (SD) mm3 (Ad-GFP/vehicle, n = 8), 49.29 ± 9.39 mm3 (Ad-GFP/macitentan, n = 8), 61.5 ± 9.49 mm3 (Ad-EDNRB/vehicle, n = 8), 73.75 ± 12.75 mm3 (Ad-EDNRB/macitentan, n = 8), with no significant difference among the groups (Fig. 4D). The gene discussed is EDNRB; the disease is neoplasm.