A2M and neoplasm: Immunity-related pathways including allograft rejection, interferon (IFN)-α or IFN-γ response, and the IL6-JAK-STAT3 signaling were down-regulated in tumor samples and they were enriched with Signature 17 negatively correlated genes (e.g., CXCR3, A2M, and FGL2), suggesting suppressed immune response in Signature 17-high tumors.