BRDT and malignant colon neoplasm: Recent studies have shown that BRDT is reactivated and expressed in various human cancers, including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinomas (HNSCC) and esophagus squamous cell carcinomas, but not in melanoma or in cancers of the colon, breast, kidney and bladder6,28,30.