To test the link between BRDT depletion-induced anti-ovarian cancer cell activity and PLK1-AURKC downregulation, BRDT-KO CaOV3 cells were further transfected with lentivirus encoding PLK1 and AURKC (“ + lv-PLK1 + lv-AURKC”). The gene discussed is PLK1; the disease is ovarian cancer.