Analyses of the TCGA HCC cohort (TCGA-LIHC) revealed that tumors with chromosome 8p LOH had higher mRNA levels of the STAT3 target genes SPINK1, SOAT2, MYBL2, and AURKB than tumors without chromosome 8p aberration (Fig. S1; Table S1). Here, SPINK1 is linked to hepatocellular carcinoma.