RHBDF2 and Alzheimer disease: Our meta-analysis of individual CpGs identified many of the loci previously reported in single cohort DNA methylation analysis8,14–16 include genes such as HOXA3, ANK1, RHBDF2, SLC44A2, and BIN1. Notably, among the 3751 FDR significant CpGs (Supplementary Data 1), 151 CpGs were mapped to the group of HOX genes on chromosome 7, where aberrant methylation in a 48 kb region near the HOXA gene cluster has been shown to be associated with AD neuropathology in multiple AD EWAS datasets14–16.