Chemokines, which direct the migration of leukocytes throughout the body44, are another large group of remodeled cytokines involved in antitumor immunity pathway, such as CCR6, CXCL16, CCL7, etc. Most importantly, ZD55-IL-24 therapy can result in substantial increase of effector molecules (TRAIL, TNF-β, Granzyme B, etc.), which directly induce the death of tumor cells in tumors, indicating the good prognosis of ZD55-IL-24 therapy. Here, GZMB is linked to neoplasm.