Together, our data show that ZD55-IL-24 can induce antitumor immunity in B16-bearing immunocompetent mouse model largely due to its ability to turn the tumor cells from the “self” state into the “nonself” state, but not due to its ability to lyse tumor cells and release TAAs, PAMPs, DAMPs as well as cytokines. The gene discussed is IL24; the disease is neoplasm.