IL24 and neoplasm: Importantly, we simultaneously noticed that the UV-inactivated ZD55-IL-24 that has the ability of viral attachment and entry, but has a damaged viral DNA, also failed to induce antitumor immunity (Fig. 6A–E), further suggesting that the “nonself” state turning process of tumor cells induced by ZD55-IL-24 was dependent on the action of viral DNA in tumor cells.