IL24 and melanoma: Through analysis of the above down-regulated and up-regulated cytokines (Fig. 2A–D), we also noticed that 4 down-regulated cytokines had a function of promoting angiogenesis (Fig. 7A) and 9 up-regulated cytokines had a function of suppressing angiogenesis (Fig. 7B), hinting that ZD55-IL-24 might inhibit melanoma growth in B16-bearing immunocompetent mouse model also through inhibiting angiogenesis.