BRD4 and Duchenne muscular dystrophy: Based on our initial data (Fig. 1) and our previous observation that BRD4 blockade ameliorates glucocorticoid-induced atrophy in C2C12 myotubes, as well as taking into account the well-documented anti-inflammatory effect of BET inhibitors33,35 we hypothesized that JQ1 treatment may ameliorate the dystrophic phenotype in the mdx mouse model of DMD.