Additionally, the enhanced proliferation and migration ability of TMEM98 overexpression plasmid transfected HNSCC cells could be reversed after the treatment of MK-2206 2HCL, an inhibitor of AKT/GSK3β /Cyclin D1 signaling (Supplementary Figure 1B, 1C). This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.