Microglia cells treated with 5 μM OLT1177 showed a significantly reduced release of each of these cytokines compared to cells treated with LPS alone (Fig. 5), supporting the hypothesis that OLT1177 leads to a rescue of the AD phenotype in APP/PS1 mice via a reduction of a general proinflammatory response at the cellular level in the CNS. The gene discussed is PSEN1; the disease is Alzheimer disease.