Considering the different histopathology between early-onset and late-onset FGR (or preeclampsia), the downregulated LGALS1 expression in early-onset FGR speculatively contributes directly to placental insufficiency, while the upregulated expression observed in late-onset FGR might be secondary to relative placental–umbilical hypoxia or reduced umbilical flow [30, 32, 34]. Here, LGALS1 is linked to placental insufficiency.