The significant tumor regressions and pathological responses achieved, following combined treatments of the tumors that displayed the highest expression of EGFR and the highest percentage of tumor cells with ≥ 4 EGFR copies (HCI-010 and HCI-025), suggest that navitoclax+ABBV-321 would be an effective treatment option for previously treated advanced/metastatic TNBC that express high levels of EGFR. Here, EGFR is linked to neoplasm.