AB095-PBD (non-tumor targeted ADC) and navitoclax+AB095-PBD also caused reductions in tumor volume and regressions in the HCI-010 and HCI-025 PDX models; however, responses to ABBV-321 alone were significantly greater than to AB095-PBD alone, and the responses to navitoclax+ABBV-321 were greater than navitoclax+AB095-PBD, supporting a contribution of EGFR-targeted effects to the efficacy of ABBV-321. Here, EGFR is linked to neoplasm.