Depletion of macrophages and myeloid cells (anti-CSF1R) had little to no impact on the anti-tumor activity of hAB21, whereas depletion of neutrophils (anti-GR1) and CD8+ (anti-CD8) T cells abrogated anti-tumor activity (Fig. 4) indicating a requirement for both innate and adaptive immunity. This evidence concerns the gene CD8A and neoplasm.