Hepatic CSCs are considered as one of the determining factors for HCC carcinogenesis and recurrence and multiple hepatic CSC biomarkers such as EpCAM, CD133, CD90, CD44, and CD24, have been used to enrich tumorigenic CSCs in both HCC cell lines and primary HCC tissues [13–19] . The gene discussed is EPCAM; the disease is hepatocellular carcinoma.