Curcumin modulates the several cellular transduction pathways and molecular targets (advanced glycation end-product (AGE)-mediated induction of the receptor for AGE gene expression, de novo synthesis of glutathione, PPARγ activity, NF-kB, STAT-3, Nrf2, TNF-α, IL-1β, resistin and leptin, adiponectin, etc.)which might lead to its therapeutic role in obesity and some obesity-related metabolic diseases such as T2DM [23–25]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.