In addition, we observed a high frequency of the increased pain tolerance, gait abnormalities, repetitive behaviors, regression, and minor dysmorphic traits including ear anomalies and descending palpebral fissure in loss of SHANK3 alone group which are in line with previous estimates in individuals with PMS due to SHANK3 point mutations [28]. This evidence concerns the gene SHANK3 and premenstrual tension.