Univariate analysis identified seven significant factors: (1) gender (p = 0.04), (2) past history of extra-thoracic metastasis (p = 0.04), (3) maximum tumor size (p = 0.002), (4) mediastinal lymph node metastasis (p = 0.02), (5) preoperative CEA level (p = 0.01), (6) preoperative CA19-9 level (p = 0.03), and (7) repeat pulmonary metastasectomy for pulmonary recurrence (p < 0.001). This evidence concerns the gene CEACAM5 and metastatic malignant neoplasm in the lymph nodes.