Other serum biomarkers, such as D-dimer [17, 18], interleukin-6 [19], tumor necrosis factor-α [20], procalcitonin (PCT), and α-defensin [21, 22], have been researched for diagnosing PJI, but these parameters are not easily accessible in some remote areas, and larger-scale studies are still needed to validate their effectiveness. The gene discussed is TNF; the disease is juvenile polyposis syndrome.