TNF and obesity due to melanocortin 4 receptor deficiency: Interestingly, Biocarta also found significant overrepresentation in two well-known anti-inflammatory pathways: the PPARγ-related obesity pathway (Systemic name M22017) and the IL-10/JAK/STAT signaling pathway that result in the repression of TNFα, IL-1, and IL-6 (Systemic name M6778) (Table 2).