In contrast, several genes including PMP22 (p < 0.0001), GSTP1 (p < 0.0001), and CST3 (p < 0.0001) had significantly decreased expression in PCa specimens as compared with that of benign prostate, and a few genes including CCNA1 (p = 0.112), PSCA (p = 0.187), and PTEN (p = 0.493) had statistically insignificant decrease in gene expression (Additional file 3: Fig. S2). This evidence concerns the gene CST3 and posterior cortical atrophy.