The 25-Gene Panel consists of several known PCa-specific biomarkers (PCA3, TMPRSS2); biomarkers with potential diagnostic or prognostic values (ANXA3, CRISP3, CST3, KLK3, PSCA, EZH2, GSTP1, AMACR); biomarkers associated with cellular functions including proliferation, survival, migration, and metastasis (FGFR1, CCNA1, CDK1, CCND1, HIF1A, HPN, VEGFA, PTEN, PIP5K1A); and biomarkers whose involvement in cancer remains unknown (LMTK2, MYO6, BIRC5, FN1, GOLPH2, PMP22) [29–34]. Here, HPN is linked to cancer.